Responsable : Fabrice FLEURY

 

Projets et objectifs:

L’objectif de notre équipe est de comprendre les mécanismes moléculaires et biochimiques de la réparation de l’ADN, notamment par recombinaison homologue (RH), et d’explorer certaines voies de réparation impliquées dans les processus de résistance aux traitements anticancéreux.
Nous étudions en particulier Rad51, protéine clef de la RH fréquemment surexprimée dans les cellules cancéreuses et qui est à l’origine de résistance aux radio- et chimio-thérapies anticancéreuses.
Les interactions impliquant des protéines de réparation de l’ADN sont étudiées par criblage à haut débit (Puces à protéines). Leur caractérisation et leur analyse structure-fonction sont abordées par un ensemble d’outils biophysiques (disponibles via la plate-forme IMPACT) parfaitement maîtrisés par notre équipe. Les informations moléculaires ainsi extraites sont ensuite exploitées pour mieux comprendre les régulations au niveau cellulaire. Cette interface moléculaire-cellulaire est l’un des points forts qui caractérise notre équipe.

 

  1. Développement d’inhibiteurs de RAD51
  2. Rôle des modifications post-traductionnelles dans la régulation fonctionnelle de RAD51
  3. Approches biotechnologiques

Mots-clés : , , ,

Membres

Anciens membres de l'équipe


Projets

Publications

5 publications

Rey, Verónica; Tornín, Juan; Alba-Linares, Juan Jose; Robledo, Cristina; Murillo, Dzohara; Rodríguez, Aida; Gallego, Borja; Huergo, Carmen; Viera, Cristina; Braña, Alejandro; Astudillo, Aurora; Heymann, Dominique; Szuhai, Karoly; Bovée, Judith V M G; Fernández, Agustín F; Fraga, Mario F; Alonso, Javier; Rodríguez, René

A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma Article de journal

Dans: EBioMedicine, vol. 102, p. 105090, 2024, ISSN: 2352-3964.

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Evin, Manon; Koumeir, Charbel; Bongrand, Arthur; Delpon, Gregory; Haddad, Ferid; Mouchard, Quentin; Potiron, Vincent; Saade, Gaëlle; Servagent, Noël; Villoing, Daphnée; Métivier, Vincent; Chiavassa, Sophie

Methodology for small animals targeted irradiations at conventional and ultra-high dose rates 65 MeV proton beam Article de journal

Dans: Phys Med, vol. 120, p. 103332, 2024, ISSN: 1724-191X.

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Nifontova, Galina; Charlier, Cathy; Ayadi, Nizar; Fleury, Fabrice; Karaulov, Alexander; Sukhanova, Alyona; Nabiev, Igor

Photonic Crystal Surface Mode Real-Time Imaging of RAD51 DNA Repair Protein Interaction with the ssDNA Substrate Article de journal

Dans: Biosensors, vol. 14, no. 1, 2024, ISSN: 2079-6374.

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Jubelin, Camille; Muñoz-Garcia, Javier; Ollivier, Emilie; Cochonneau, Denis; Vallette, François; Heymann, Marie-Françoise; Oliver, Lisa; Heymann, Dominique

Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, p. 119660, 2024, ISSN: 0167-4889.

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Renodon-Corniere, Axelle; Mikawa, Tsutomu; Kuwabara, Naoyuki; Ito, Kentaro; Levitsky, Dmitri; Iwasaki, Hiroshi; Takahashi, Masayuki

Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange Article de journal

Dans: International Journal of Molecular Sciences, vol. 25, no. 7, 2024, ISSN: 1422-0067.

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20 publications

Panez-Toro, Isidora; Heymann, Dominique; Gouin, François; Amiaud, Jérôme; Heymann, Marie-Françoise; Córdova, Luis A.

Roles of inflammatory cell infiltrate in periprosthetic osteolysis Article de journal

Dans: Frontiers in Immunology, vol. 14, p. 1310262, 2023, ISSN: 1664-3224.

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Evgeniia Gerasimovich Galina Nifontova, Fabrice Fleury

Photonic Crystal Surface Mode Imaging for Multiplexed Real-Time Detection of Antibodies, Oligonucleotides, and DNA Repair Proteins Article de journal

Dans: EPJ Web of Conferences, vol. 287, 2023.

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Charbel Koumeir Manon Evin, Quentin Mouchard

Dosimetric environment of preclinical FLASH hadrontherapy studies at the ARRONAX cyclotron Conférence

2023.

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Charbel Koumeir Manon Evin, Quentin Mouchard

Dosimetric environment and first results of the studies on the physicochemical and biological mechanisms of FLASH hadrontherapy at the ARRONAX cyclotron Conférence

2023.

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Dubois, Nolwenn; Muñoz-Garcia, Javier; Heymann, Dominique; Renodon-Cornière, Axelle

High glucose exposure drives intestinal barrier dysfunction by altering its morphological, structural and functional properties. Article de journal

Dans: Biochemical pharmacology, vol. 216, p. 115765, 2023, ISSN: 1873-2968 0006-2952, (Place: England).

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Ghannam, Youssef; Chiavassa, Sophie; Saade, Gaëlle; Koumeir, Charbel; Blain, Guillaume; Delpon, Grégory; Evin, Manon; Haddad, Ferid; Maigne, Lydia; Mouchard, Quentin; Servagent, Noël; Potiron, Vincent; Supiot, Stéphane

First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos Article de journal

Dans: Radiother Oncol, vol. 187, p. 109820, 2023, ISSN: 1879-0887.

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Pu, Yi; Li, Lu; Peng, Haoning; Liu, Lunxu; Heymann, Dominique; Robert, Caroline; Vallette, François; Shen, Shensi

Drug-tolerant persister cells in cancer: the cutting edges and future directions Article de journal

Dans: Nature Reviews Clinical Oncology, 2023, ISSN: 1759-4782.

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Antoine, Babuty; Boisseau, Pierre; Drillaud, Nicolas; Eveillard, Marion; Fouassier, Marc

MYH9-related disease: Assessment of the pathogenicity of a new mutation Article de journal

Dans: EJHaem, vol. 4, no. 3, p. 869–871, 2023, ISSN: 2688-6146.

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Muñoz-Garcia, Javier; Heymann, Dominique; Giurgea, Irina; Legendre, Marie; Amselem, Serge; Castañeda, Beatriz; Lézot, Frédéric; Vargas-Franco, Jorge William

Pharmacological options in the treatment of osteogenesis imperfecta: A comprehensive review of clinical and potential alternatives Article de journal

Dans: Biochem Pharmacol, vol. 213, p. 115584, 2023, ISSN: 1873-2968.

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Panez-Toro, Isidora; Muñoz-García, Javier; Vargas-Franco, Jorge W.; Renodon-Cornière, Axelle; Heymann, Marie-Françoise; Lézot, Frédéric; Heymann, Dominique

Advances in Osteosarcoma Article de journal

Dans: Current Osteoporosis Reports, 2023, ISSN: 1544-1873, 1544-2241.

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Loussouarn, Delphine; Oliver, Lisa; Salaud, Celine; Samarut, Edouard; Bourgade, Raphaël; Béroud, Christophe; Morenton, Emilie; Heymann, Dominique; Vallette, Francois M.

Spatial Distribution of Immune Cells in Primary and Recurrent Glioblastoma: A Small Case Study Article de journal

Dans: Cancers, vol. 15, no. 12, p. 3256, 2023, ISSN: 2072-6694.

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Charbel Koumeir Manon Evin, Quentin Mouchard

Environnement dosimétrique et premiers résultats des études sur les mécanismes physico-chimiques et biologiques de l'hadronthérapie FLASH au cyclotron ARRONAX Conférence

2023.

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Metz, Raphaël; Rauscher, Aurore; Vaugier, Loïg; Supiot, Stéphane; Drouet, Franck; Campion, Loic; Rousseau, Caroline

Comparison of Hormone-Sensitive Oligorecurrent Prostate Cancer Patients Based on Routine Use of Choline and/or PSMA PET/CT to Guide Metastasis-Directed Therapy Article de journal

Dans: Cancers, vol. 15, no. 6, 2023, ISSN: 2072-6694.

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Demeyer, Alexandre; Fonteneau, Lucie; Liennard, Marion; Foyer, Claire; Weigel, Pierre; Laurent, Adèle; Lebreton, Jacques; Fleury, Fabrice; Mathé-Allainmat, Monique

Synthesis and Biological Evaluation of DIDS Analogues as Efficient Inhibitors of RAD51 Involved in Homologous Recombination Article de journal

Dans: Bioorg Med Chem Lett, p. 129261, 2023, ISSN: 1464-3405.

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Saade, Gaëlle; Bogaerts, Eva; Chiavassa, Sophie; Blain, Guillaume; Delpon, Grégory; Evin, Manon; Ghannam, Youssef; Haddad, Ferid; Haustermans, Karin; Koumeir, Charbel; others,

Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos Article de journal

Dans: Advances in Radiation Oncology, vol. 8, no. 2, p. 101124, 2023.

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Nifontova, Galina; Petrova, Irina; Gerasimovich, Evgeniia; Konopsky, Valery N.; Ayadi, Nizar; Charlier, Cathy; Fleury, Fabrice; Karaulov, Alexander; Sukhanova, Alyona; Nabiev, Igor

Label-Free Multiplexed Microfluidic Analysis of Protein Interactions Based on Photonic Crystal Surface Mode Imaging Article de journal

Dans: International Journal of Molecular Sciences, vol. 24, no. 5, 2023, ISSN: 1422-0067.

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Madel, Maria-Bernadette; Halper, Julia; Ibáñez, Lidia; Claire, Lozano; Rouleau, Matthieu; Boutin, Antoine; Mahler, Adrien; Pontier-Bres, Rodolphe; Ciucci, Thomas; Topi, Majlinda; Hue, Christophe; Amiaud, Jerome; Iborra, Salvador; Sancho, David; Heymann, Dominique; Garchon, Henri-Jean; Czerucka, Dorota; Apparailly, Florence; Duroux-Richard, Isabelle; Wakkach, Abdelilah; Blin-Wakkach, Claudine

Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis Article de journal

Dans: eLife, vol. 12, p. e82037, 2023, ISSN: 2050-084X.

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Oliver, Lisa; Álvarez-Arenas, Arturo; Salaud, Céline; Jiménez-Sanchez, Juan; Calvo, Gabriel F.; Belmonte-Beitia, Juan; Blandin, Stephanie; Vidal, Luciano; Pérez, Victor; Heymann, Dominique; Vallette, François M.

A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma Article de journal

Dans: Cancers, vol. 15, no. 4, 2023, ISSN: 2072-6694.

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Jacquot, Perrine; Muñoz-Garcia, Javier; Fleury, Maurine; Cochonneau, Denis; Gaussin, Rémi; Enouf, Elise; Roze, Caroline; Ollivier, Emilie; Cinier, Mathieu; Heymann, Dominique

Engineering of a Bispecific Nanofitin with Immune Checkpoint Inhibitory Activity Conditioned by the Cross-Arm Binding to EGFR and PDL1 Article de journal

Dans: Biomolecules, vol. 13, no. 4, 2023, ISSN: 2218-273X.

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Jubelin, Camille; Muñoz-Garcia, Javier; Cochonneau, Denis; Ollivier, Emilie; Vallette, François; Heymann, Marie-Françoise; Oliver, Lisa; Heymann, Dominique

Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements Article de journal

Dans: Front Bioeng Biotechnol, vol. 11, p. 1260049, 2023, ISSN: 2296-4185.

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19 publications

CHALOPIN, Antoine

Caractérisation des cellules tumorales circulantes de sarcomes osseux : identification de nouveaux marqueurs de la pathologie recidivante Thèse

2022.

Liens | BibTeX

Beird, Hannah C; Bielack, Stefan S; Flanagan, Adrienne M; Gill, Jonathan; Heymann, Dominique; Janeway, Katherine A; Livingston, J Andrew; Roberts, Ryan D; Strauss, Sandra J; Gorlick, Richard

Osteosarcoma Article de journal

Dans: Nat Rev Dis Primers, vol. 8, no. 1, p. 77, 2022, ISSN: 2056-676X.

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Vincent Potiron Gaëlle Saade, Stéphane Supiot

Reduction of radiotoxicity by ultra-high dose rate protontherapy in zebrafish embryos Conférence

2022.

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Potiron, V; Delpon, G; Ollivier, L; Vaugier, L; Doré, M; Guimas, V; Rio, E; Thillays, F; Llagostera, C; Moignier, A; Josset, S; Chiavassa, S; Perennec, T; Supiot, S

[Clinical research in radiation oncology: how to move from the laboratory to the patient?] Article de journal

Dans: Cancer Radiother, vol. 26, no. 6-7, p. 808–813, 2022, ISSN: 1769-6658.

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Heymann, Clément J F; Bobin-Dubigeon, Christine; Muñoz-Garcia, Javier; Cochonneau, Denis; Ollivier, Emilie; Heymann, Marie-Françoise; Heymann, Dominique

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients Article de journal

Dans: J Bone Oncol, vol. 36, p. 100451, 2022, ISSN: 2212-1366.

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Léost, Françoise; Delpon, Grégory; Garcion, Emmanuel; Gestin, Jean-François; Hatt, Mathieu; Potiron, Vincent; Rbah-Vidal, Latifa; Supiot, Stéphane

Adaptation of the tumour and its ecosystem to radiotherapies: Mechanisms, imaging and therapeutic approaches » XIVe édition du workshop organisé par le réseau « Vectorisation, Imagerie, Radiothérapies » du Cancéropôle Grand-Ouest, 22–25 septembre 2021, Le Bono, France Actes

vol. 109, no. 10, 2022, ISSN: 1769-6917.

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Guillaume Blain Giovanna Rosa Fois, Sophie Chiavassa

Microdosimetry and radiolytic species production in UHDR proton beam using GATE and Geant4-DNA Conférence

2022.

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Rodríguez-Pena, Alejandro; Armendariz, Estibaliz; Oyarbide, Alvaro; Morales, Xabier; Ortiz-Espinosa, Sergio; de Córdoba, Borja Ruiz-Fernández; Cochonneau, Denis; Cornago, Iñaki; Heymann, Dominique; Argemi, Josepmaría; D'Avola, Delia; Sangro, Bruno; Lecanda, Fernando; Pio, Ruben; Cortés-Domínguez, Iván; Ortiz-de-Solórzano, Carlos

Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood Article de journal

Dans: Bioeng Transl Med, vol. 7, no. 3, p. e10331, 2022, ISSN: 2380-6761.

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Jubelin, Camille; Muñoz-Garcia, Javier; Griscom, Laurent; Cochonneau, Denis; Ollivier, Emilie; Heymann, Marie-Françoise; Vallette, François M; Oliver, Lisa; Heymann, Dominique

Three-dimensional in vitro culture models in oncology research Article de journal

Dans: Cell Biosci, vol. 12, no. 1, p. 155, 2022, ISSN: 2045-3701.

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Ollivier, Luc; Orione, Charles; Bore, Paul; Misery, Laurent; Legoupil, Delphine; Leclere, Jean-Christophe; Coste, Anne; Girault, Gilles; Sicard-Cras, Iona; Kacperek, Clemence; Lucia, Francois; Stefan, Dinu; Thillays, François; Rio, Emmanuel; Lesueur, Paul; Berthou, Christian; Heymann, Dominique; Champiat, Stéphane; Supiot, Stéphane; Vaugier, Loig; Kao, William

Abscopal Response in Metastatic Melanoma: Real-World Data of a Retrospective, Multicenter Study Article de journal

Dans: Cancers (Basel), vol. 14, no. 17, 2022, ISSN: 2072-6694.

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Bertorelle, Franck; Wegner, K David; Bakulić, Martina Perić; Fakhouri, Hussein; Comby-Zerbino, Clothilde; Sagar, Amin; Bernadó, Pau; Resch-Genger, Ute; Bonačić-Koutecký, Vlasta; Guével, Xavier Le; Antoine, Rodolphe

Tailoring the NIR-II Photoluminescence of Single Thiolated Au Nanoclusters by Selective Binding to Proteins Article de journal

Dans: Chemistry, vol. 28, no. 39, p. e202200570, 2022, ISSN: 1521-3765.

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Jubelin, Camille; Cochonneau, Denis; Moranton, Emilie; Munoz-Garcia, Javier; Heymann, Dominique

Circulating Tumor Cells and ctDNA in Sarcomas Chapitre d'ouvrage

Dans: Leong, Stanley P.; Nathanson, S. David; Zager, Jonathan S. (Ed.): Cancer Metastasis Through the Lymphovascular System, p. 121–128, Springer, 2022.

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Guillaume Blain Vincent Fiegel, Manon Evin

Hydrogen peroxide formation to investigate the radiolytic ROS production mechanism under proton FLASH conditions Conférence

2022.

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de Cordoba, Borja Ruiz-Fernandez; Moreno, Haritz; Valencia, Karmele; Perurena, Naiara; Ruedas, Pablo; Walle, Thomas; Pezonaga-Torres, Alberto; Hinojosa, Juan; Guruceaga, Elisabet; Pineda-Lucena, Antonio; Abengozar-Muela, Marta; Cochonneau, Denis; Zandueta, Carolina; Martinez-Canarias, Susana; Teijeira, Alvaro; Ajona, Daniel; Ortiz-Espinosa, Sergio; Morales, Xabier; de Solorzano, Carlos Ortiz; Santisteban, Marta; Ramos-Garcia, Luis I; Guembe, Laura; Strnad, Vratislav; Heymann, Dominique; Hervas-Stubbs, Sandra; Pio, Ruben; Rodriguez-Ruiz, Maria E; de Andrea, Carlos E; Vicent, Silvestre; Melero, Ignacio; Lecanda, Fernando; Martinez-Monge, Rafael

Tumor ENPP1(CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer Article de journal

Dans: Cancer Discov, vol. 12, no. 5, p. 1356-1377, 2022, ISSN: 2159-8290.

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Villoing, Daphnée; Koumeir, Charbel; Bongrand, Arthur; Guertin, Arnaud; Haddad, Ferid; Métivier, Vincent; Poirier, Freddy; Potiron, Vincent; Servagent, Noël; Supiot, Stéphane; Delpon, Grégory; Chiavassa, Sophie

Technical note: Proton beam dosimetry at ultra-high dose rates (FLASH): Evaluation of GAFchromic™ (EBT3, EBT-XD) and OrthoChromic (OC-1) film performances Article de journal

Dans: Med Phys, vol. 49, no. 4, p. 2732–2745, 2022, ISSN: 2473-4209.

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Muñoz-Garcia, Javier; Vargas-Franco, Jorge William; Royer, Bénédicte Brounais-Le; Cochonneau, Denis; Amiaud, Jérôme; Heymann, Marie-Françoise; Heymann, Dominique; Lézot, Frédéric

Inhibiting Endothelin Receptors with Macitentan Strengthens the Bone Protective Action of RANKL Inhibition and Reduces Metastatic Dissemination in Osteosarcoma Article de journal

Dans: Cancers, vol. 14, no. 7, p. 1765, 2022, ISSN: 2072-6694.

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Jubelin, Camille; Munoz-Garcia, Javier; Cochonneau, Denis; Moranton, Emilie; Heymann, Marie Françoise; Heymann, Dominique

Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma Article de journal

Dans: Cancer Drug Resistance, vol. 5, iss. 5, p. 184-198, 2022.

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Cadé, Marie; Muñoz-Garcia, Javier; Babuty, Antoine; Paré, Louis; Cochonneau, Denis; Fekir, Karim; Chatelais, Mathias; Heymann, Marie-Françoise; Lokajczyk, Anna; Boisson-Vidal, Catherine; Heymann, Dominique

FVIII regulates the molecular profile of endothelial cells: functional impact on the blood barrier and macrophage behavior Article de journal

Dans: Cell Mol Life Sci, vol. 79, no. 3, p. 145, 2022, ISSN: 1420-9071.

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Colliec-Jouault, Sylvia; Sinquin, Corinne; Ratiskol, Jacqueline; Heymann, Dominique; Ruiz-Velasco, Carmen; Chesneau, Julie

Anti-metastatic marine bacterial exopolysaccharide derivative and uses thereof Patent

2022, (US Patent 11,219,638).

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6 publications

Charbel Koumeir Noël Servagent, Guillaume Blain

Proton beam FLASH online monitoring at ARRONAX cyclotron Conférence

2021.

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UHDR proton beam vs conventional: hydrogen peroxide as FLASH effect sensor Conférence

2021.

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Velic, Denis; Demeyer, Alexandre; Peterlini, Thibaut; Benhelli-Mokrani, Houda; Mathé-Allainmat, Monique; Masson, Jean-Yves; Fleury, Fabrice

Molecular Determinant of DIDS Analogs Targeting RAD51 Activity Article de journal

Dans: Molecules, vol. 26, no. 18, p. 5460, 2021, ISSN: 1420-3049.

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Demeyer, Alexandre; Benhelli-Mokrani, Houda; Chénais, B.; Weigel, Pierre; Fleury, Fabrice

Inhibiting homologous recombination by targeting RAD51 protein Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1876, no. 2, p. 188597, 2021, ISSN: 0304419X.

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Le, Van-Tuyen; Bertrand, Samuel; du Pont, Thibaut Robiou; Fleury, Fabrice; Caroff, Nathalie; Bourgeade-Delmas, Sandra; Gentil, Emmanuel; Logé, Cedric; Genta-Jouve, Gregory; Grovel, Olivier

Untargeted Metabolomics Approach for the Discovery of Environment-Related Pyran-2-Ones Chemodiversity in a Marine-Sourced Penicillium restrictum Article de journal

Dans: Marine Drugs, vol. 19, no. 7, p. 378, 2021, ISSN: 1660-3397.

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Muñoz-Garcia, Javier; Cochonneau, Denis; Télétchéa, Stéphane; Moranton, Emilie; Lanoe, Didier; Brion, Régis; Lézot, Frédéric; Heymann, Marie-Françoise; Heymann, Dominique

The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis Article de journal

Dans: Theranostics, vol. 11, no. 4, p. 1568–1593, 2021, ISSN: 1838-7640.

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10 publications

Chabot, Thomas; Cheraud, Yvonnick; Fleury, Fabrice

Relationships between DNA repair and RTK-mediated signaling pathways Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, p. 188495, 2020, ISSN: 0304419X.

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Méresse, Sarah; Fodil, Mostefa; Fleury, Fabrice; Chénais, Benoît

Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy Article de journal

Dans: International Journal of Molecular Sciences, vol. 21, no. 23, p. 9273, 2020, ISSN: 1422-0067.

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Chabot, Thomas

Modulation de l'activité du Rad51 par le récepteur tyrosine kinase c-Met dans la réparation des cassures double-brin de l'ADN Thèse

Université de Nantes, 2020, (294 pages).

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Fleury, Fabrice; Demeyer, Alexandre; Weigel, Pierre; Chenais, Benoit; Mathé, Monique; Lebreton, Jacques

Disulfonate stilbenes for use in the treatment of proliferative diseases Patent

WO2020104634A1, 2020.

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Ayadi, Nizar; Lafont, Florian; Charlier, Cathy; Benhelli-Mokrani, Houda; Sokolov, Pavel; Sukhanova, Alyona; Fleury, Fabrice; Nabiev, Igor

Comparative Advantages and Limitations of Quantum Dots in Protein Array Applications Chapitre d'ouvrage

Dans: Quantum Dots, vol. 2135, p. 259–273, Springer, New York, NY, Humana, 2020.

BibTeX

Yaremenko, Ivan A; Coghi, Paolo; Prommana, Parichat; Qiu, Congling; Radulov, Peter S; Qu, Yuanqing; Belyakova, Yulia Yu; Zanforlin, Enrico; Kokorekin, Vladimir A; Wu, Yuki Yu Jun; Fleury, Fabrice; Uthaipibull, Chairat; Wong, Vincent Kam Wai; Terent'ev, Alexander O

Synthetic Peroxides Promote Apoptosis of Cancer Cells by Inhibiting P-Glycoprotein ABCB5 Article de journal

Dans: ChemMedChem, vol. 15, no. 13, p. 1118–1127, 2020, ISSN: 18607187.

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Aganyants, Hovsep; Weigel, Pierre; Hovhannisyan, Yeranuhi; Lecocq, Michèle; Koloyan, Haykanush; Hambardzumyan, Artur; Hovsepyan, Anichka; Hallet, Jean Noël; Sakanyan, Vehary

Rational engineering of the substrate specificity of a thermostable d-hydantoinase (Dihydropyrimidinase) Article de journal

Dans: High-Throughput, vol. 9, no. 1, 2020, ISSN: 25715135.

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Yaremenko, Ivan A; Radulov, Peter S; Belyakova, Yulia Yu; Demina, Arina A; Fomenkov, Dmitriy I; Barsukov, Denis V; Subbotina, Irina R; Fleury, Fabrice; Terent'ev, Alexander O

Catalyst Development for the Synthesis of Ozonides and Tetraoxanes Under Heterogeneous Conditions: Disclosure of an Unprecedented Class of Fungicides for Agricultural Application Article de journal

Dans: Chemistry - A European Journal, vol. 26, no. 21, p. 4734–4751, 2020, ISSN: 15213765.

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Lafont, Florian; Fleury, Fabrice; Benhelli-Mokrani, Houda

DNA-PKcs Ser2056 auto-phosphorylation is affected by an O-GlcNAcylation/phosphorylation interplay Article de journal

Dans: Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1864, no. 12, p. 129705, 2020, ISSN: 0304-4165.

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Vil', Vera A; Yaremenko, Ivan A; Fomenkov, Dmitri I; Levitsky, Dmitri O; Fleury, Fabrice; Terent'ev, Alexander O

Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells Article de journal

Dans: Chemistry of Heterocyclic Compounds, vol. 56, no. 6, p. 722–726, 2020, ISSN: 1573-8353.

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2 publications

Velic, Denis; Charlier, Cathy; Popova, Milena; Jaunet-Lahary, Titouan; Bouchouireb, Zakaria; Henry, Sébastien; Weigel, Pierre; Masson, Jean-Yves; Laurent, Adèle D; Nabiev, Igor; Fleury, Fabrice

Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches Article de journal

Dans: Biochimie, vol. 167, p. 187–197, 2019, ISSN: 0300-9084.

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Chabot, Thomas; Defontaine, Alain; Marquis, Damien; Renodon-Corniere, Axelle; Courtois, Emmanuelle; Fleury, Fabrice; Cheraud, Yvonnick

New phosphorylation sites of rad51 by c-met modulates presynaptic filament stability Article de journal

Dans: Cancers, vol. 11, no. 3, 2019, ISSN: 20726694.

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4 publications

Benhelli-Mokrani, Houda; Mansuroglu, Zeyni; Chauderlier, Alban; Albaud, Benoit; Gentien, David; Sommer, Sabrina; Schirmer, Claire; Laqueuvre, Lucie; Josse, Thibaut; Buée, Luc; Lefebvre, Bruno; Galas, Marie Christine; Souès, Sylvie; Bonnefoy, Eliette

Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions Article de journal

Dans: Nucleic acids research, vol. 46, no. 21, p. 11405–11422, 2018, ISSN: 13624962.

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Deriabin, Konstantin V; Yaremenko, Ivan A; Chislov, Mikhail V; Fleury, Fabrice; Terent'Ev, Alexander O; Islamova, Regina M

Similar nature leads to improved properties: Cyclic organosilicon triperoxides as promising curing agents for liquid polysiloxanes Article de journal

Dans: New Journal of Chemistry, vol. 42, no. 18, p. 15006–15013, 2018, ISSN: 13699261.

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Lafont, Florian; Ayadi, Nizar; Charlier, Cathy; Weigel, Pierre; Nabiev, Igor; Benhelli-Mokrani, Houda; Fleury, Fabrice

Assessment of DNA-PKcs kinase activity by quantum dot–based microarray Article de journal

Dans: Scientific Reports, vol. 8, no. 1, p. 1–12, 2018, ISSN: 20452322.

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Jaunet-Lahary, Titouan; Vercauteren, Daniel P; Fleury, Fabrice; Laurent, Adèle D

Computational simulations determining disulfonic stilbene derivative bioavailability within human serum albumin Article de journal

Dans: Physical Chemistry Chemical Physics, vol. 20, no. 26, p. 18020–18030, 2018, ISSN: 14639076.

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5 publications

Bosseboeuf, Adrien; Feron, Delphine; Tallet, Anne; Rossi, Cédric; Charlier, Cathy; Garderet, Laurent; Caillot, Denis; Moreau, Philippe; Cardó-Vila, Marina; Pasqualini, Renata; Arap, Wadih; Nelson, Alfreda Destea; Wilson, Bridget S; Perreault, Hélène; Piver, Eric; Weigel, Pierre; Girodon, François; Harb, Jean; Bigot-Corbel, Edith; Hermouet, Sylvie

Monoclonal IgG in MGUS and multiple myeloma targets infectious pathogens Article de journal

Dans: JCI Insight, vol. 2, no. 19, p. 1–18, 2017, ISSN: 0021-9738.

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Yaremenko, Ivan A; Syroeshkin, Mikhail A; Levitsky, Dmitri O; Fleury, Fabrice; Terent'ev, Alexander O

Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines Article de journal

Dans: Medicinal Chemistry Research, vol. 26, no. 1, p. 170–179, 2017, ISSN: 1554-8120.

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Levitsky, Dmitri O; Gloriozova, Tatyana A; Poroikov, Vladimir V; Valery, M

ANABOLIC CYANOSTEROIDS AND THEIR BIOLOGICAL ACTIVITIES – A BRIEF REVIEW Article de journal

Dans: vol. 6, no. 12, p. 127–151, 2017, ISBN: 2017121061.

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Faucon, Adrien; Benhelli-Mokrani, Houda; Fleury, Fabrice; Dutertre, Stéphanie; Tramier, Marc; Boucard, Joanna; Lartigue, Lénaïc; Nedellec, Steven; Hulin, Philippe; Ishow, Eléna

Bioconjugated fluorescent organic nanoparticles targeting EGFR-overexpressing cancer cells Article de journal

Dans: Nanoscale, vol. 9, no. 45, p. 18094–18106, 2017, ISSN: 20403372.

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Alligand, Brendan; Breton, Magali Le; Marquis, Damien; Vallette, François; Fleury, Fabrice

Functional effects of diphosphomimetic mutations at cAbl-mediated phosphorylation sites on Rad51 recombinase activity Article de journal

Dans: Biochimie, vol. 139, p. 115–124, 2017, ISSN: 61831638.

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9 publications

Silva, Viviane A O; Lafont, Florian; Benhelli-Mokrani, Houda; Breton, Magali Le; Hulin, Philippe; Chabot, Thomas; Paris, François; Sakanyan, Vehary; Fleury, Fabrice

Rapid diminution in the level and activity of DNA-dependent protein kinase in cancer cells by a reactive nitro-benzoxadiazole compound Article de journal

Dans: International Journal of Molecular Sciences, vol. 17, no. 5, 2016, ISSN: 14220067.

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Krylov, Igor B; Kompanets, Mykhailo O; Novikova, Katerina V; Opeida, Iosip O; Kushch, Olga V; Shelimov, Boris N; Nikishin, Gennady I; Levitsky, Dmitri O; Terent'ev, Alexander O

Well-Known Mediators of Selective Oxidation with Unknown Electronic Structure: Metal-Free Generation and EPR Study of Imide-N-oxyl Radicals Article de journal

Dans: Journal of Physical Chemistry A, vol. 120, no. 1, p. 68–73, 2016, ISSN: 15205215.

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Mansuroglu, Zeyni; Benhelli-Mokrani, Houda; Marcato, Vasco; Sultan, Audrey; Violet, Marie; Chauderlier, Alban; Delattre, Lucie; Loyens, Anne; Talahari, Smail; Bégard, Séverine; Nesslany, Fabrice; Colin, Morvane; Souès, Sylvie; Lefebvre, Bruno; Buée, Luc; Galas, Marie Christine; Bonnefoy, Eliette

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin Article de journal

Dans: Scientific Reports, vol. 6, no. September, p. 1–16, 2016, ISSN: 20452322.

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Jaunet-Lahary, Titouan; Goupille, Anaïs; Jacquemin, Denis; Fleury, Fabrice; Graton, Jérôme; Laurent, Adèle D

A Joint Theoretical and Experimental Study of the Behavior of the DIDS Inhibitor and its Derivatives Article de journal

Dans: ChemPhysChem, vol. 3, p. 2434–2445, 2016, ISSN: 14397641.

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Terent'Ev, Alexander O; Pastukhova, Zhanna Yu; Yaremenko, Ivan A; Novikov, Roman A; Demchuk, Dmitry V; Bruk, Lev G; Levitsky, Dmitri O; Fleury, Fabrice; Nikishin, Gennady I

Selective transformation of tricyclic peroxides with pronounced antischistosomal activity into 2-hydroxy-1,5-diketones using iron (II) salts Article de journal

Dans: Tetrahedron, vol. 72, no. 24, p. 3421–3426, 2016, ISSN: 14645416.

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Levitsky, Dmitri O; Gloriozova, Tatyana A; Poroikov, Vladimir V; Dembitsky, Valery M

Mathews Journal of Pharmaceutical Science Naturally Occurring Isocyano / Isothiocyanato Compounds : Their Pharmacological and SAR Activities Article de journal

Dans: MATHEWS, Open Access Journals, vol. 1, no. 1, p. 1–15, 2016.

BibTeX

Zdvizhkov, Alexander T; Terent'Ev, Alexander O; Radulov, Peter S; Novikov, Roman A; Tafeenko, Viktor A; Chernyshev, Vladimir V; Ilovaisky, Alexey I; Levitsky, Dmitri O; Fleury, Fabrice; Nikishin, Gennady I

Transformation of 2-allyl-1,3-diketones to bicyclic compounds containing 1,2-dioxolane and tetrahydrofuran rings using the I2/H2O2 system Article de journal

Dans: Tetrahedron Letters, vol. 57, no. 8, p. 949–952, 2016, ISSN: 18733581.

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Sakanyan, Vehary; Hulin, Philippe; Sousa, Rodolphe Alves De; Silva, Viviane A O; Hambardzumyan, Artur; Nedellec, Steven; Tomasoni, Christophe; Logé, Cédric; Pineau, Charles; Roussakis, Christos; Fleury, Fabrice; Artaud, Isabelle

Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1 Article de journal

Dans: Scientific Reports, vol. 6, no. January, p. 1–14, 2016, ISSN: 20452322.

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Faucon, Adrien; Benhelli-Mokrani, Houda; Fleury, Fabrice; Dubreil, Laurence; Hulin, Philippe; Nedellec, Steven; Doussineau, Tristan; Antoine, Rodolphe; Orlando, Tomas; Lascialfari, Alessandro; Fresnais, Jérôme; Lartigue, Lénaïc; Ishow, Eléna

Tuning the architectural integrity of high-performance magneto-fluorescent core-shell nanoassemblies in cancer cells Article de journal

Dans: Journal of Colloid and Interface Science, vol. 479, p. 139–149, 2016, ISSN: 10957103.

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5 publications

Alligand, Brendan

Étude du rôle des phosphorylations de Rad51 en Y54 et en Y315 sur son fonctionnement Thèse

Université de Nantes, 2015.

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Faucon, Adrien; Benhelli-Mokrani, Houda; w Córdova, Luis A; Brulin, Bénédicte; Heymann, Dominique; Hulin, Philippe; Nedellec, Steven; Ishow, Eléna

Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages? Article de journal

Dans: Advanced Healthcare Materials, vol. 4, no. 17, p. 2727–2734, 2015, ISSN: 21922659.

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Qi, Haoling; Cantrelle, François Xavier; Benhelli-Mokrani, Houda; Smet-Nocca, Caroline; Buée, Luc; Lippens, Guy; Bonnefoy, Eliette; Galas, Marie Christine; Landrieu, Isabelle

Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation Article de journal

Dans: Biochemistry, vol. 54, no. 7, p. 1525–1533, 2015, ISSN: 15204995.

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Velic, Denis; Couturier, Anthony M; Ferreira, Maria Tedim; Rodrigue, Amélie; Poirier, Guy G; Fleury, Fabrice; Masson, Jean-Yves

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer Article de journal

Dans: Biomolecules, vol. 5, no. 4, p. 3204–3259, 2015, ISSN: 2218-273X.

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Terent'ev, Alexander O; Zdvizhkov, Alexander T; Levitsky, Dmitri O; Fleury, Fabrice; Pototskiy, Roman A; Kulakova, Alena N; Nikishin, Gennady I

Organocatalytic peroxidation of malonates, β-ketoesters, and cyanoacetic esters using n-Bu4NI/t-BuOOH-mediated intermolecular oxidative C(sp3)-O coupling Article de journal

Dans: Tetrahedron, vol. 71, no. 47, p. 8985–8990, 2015, ISSN: 14645416.

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