Dominique HEYMANN

Professeur - Praticien Hospitalier Université

section 42
Équipe :

Thèmes de recherche

  •  Etude de la maladie résiduelle en oncologie: approches microfluidiques, approches translationnelles, isolement et caractérisation des évènements cellulaires rares (ex: cellules tumorales circulantes).
  • Mécanismes de résistance aux drogues
    • Pathogenèse des Sarcomes Osseux (approches expérimentales in vitro et in vivo)
    • Différenciation ostéoclastique – Ostéolyses associées aux pathologies inflammatoires et cancéreuses – Etude du processus métastatique – Analyse de l’hétérogénéité tumorale
    • Biologie des cytokines
    • Fonctions extra-hémostatiques du Facteur 8

Parcours universitaire

  • 1998 – HDR, Université de Nantes
  • 1995 – PhD, Faculté de Médecine, INSERM U211, Université de Nantes
  • 1991 – Master, Université de Paris VII, INSERM

Publications

4 publications

Muñoz-Garcia, Javier; Vargas-Franco, Jorge William; Royer, Bénédicte Brounais-Le; Cochonneau, Denis; Amiaud, Jérôme; Heymann, Marie-Françoise; Heymann, Dominique; Lézot, Frédéric

Inhibiting Endothelin Receptors with Macitentan Strengthens the Bone Protective Action of RANKL Inhibition and Reduces Metastatic Dissemination in Osteosarcoma Article de journal

Dans: Cancers, vol. 14, no. 7, p. 1765, 2022, ISSN: 2072-6694.

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Jubelin, Camille; Munoz-Garcia, Javier; Cochonneau, Denis; Moranton, Emilie; Heymann, Marie Françoise; Heymann, Dominique

Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma Article de journal

Dans: Cancer Drug Resistance, vol. 5, iss. 5, p. 184-198, 2022.

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Cadé, Marie; Muñoz-Garcia, Javier; Babuty, Antoine; Paré, Louis; Cochonneau, Denis; Fekir, Karim; Chatelais, Mathias; Heymann, Marie-Françoise; Lokajczyk, Anna; Boisson-Vidal, Catherine; Heymann, Dominique

FVIII regulates the molecular profile of endothelial cells: functional impact on the blood barrier and macrophage behavior Article de journal

Dans: Cell Mol Life Sci, vol. 79, no. 3, p. 145, 2022, ISSN: 1420-9071.

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de Cordoba, Borja Ruiz-Fernandez; Moreno, Haritz; Valencia, Karmele; Perurena, Naiara; Ruedas, Pablo; Walle, Thomas; Pezonaga-Torres, Alberto; Hinojosa, Juan; Guruceaga, Elisabet; Pineda-Lucena, Antonio; Abengozar-Muela, Marta; Cochonneau, Denis; Zandueta, Carolina; Martinez-Canarias, Susana; Teijeira, Alvaro; Ajona, Daniel; Ortiz-Espinosa, Sergio; Morales, Xabier; de Solorzano, Carlos Ortiz; Santisteban, Marta; Ramos-Garcia, Luis I; Guembe, Laura; Strnad, Vratislav; Heymann, Dominique; Hervas-Stubbs, Sandra; Pio, Ruben; Rodriguez-Ruiz, Maria E; de Andrea, Carlos E; Vicent, Silvestre; Melero, Ignacio; Lecanda, Fernando; Martinez-Monge, Rafael

Tumor ENPP1(CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer Article de journal À paraître

Dans: Cancer Discov, À paraître, ISSN: 2159-8290, (10.1158/2159-8290.CD-21-0932 : ne marche pas).

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1 publication

Muñoz-Garcia, Javier; Cochonneau, Denis; Télétchéa, Stéphane; Moranton, Emilie; Lanoe, Didier; Brion, Régis; Lézot, Frédéric; Heymann, Marie-Françoise; Heymann, Dominique

The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis Article de journal

Dans: Theranostics, vol. 11, no. 4, p. 1568–1593, 2021, ISSN: 1838-7640.

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2 publications

Ségaliny, Aude I; Brion, Régis; Brulin, Bénédicte; Maillasson, Mike; Charrier, Céline; Téletchéa, Stéphane; Heymann, Dominique

IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization Article de journal

Dans: Cytokine, vol. 76, no. 2, p. 170–181, 2015, ISSN: 10960023.

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Faucon, Adrien; Benhelli-Mokrani, Houda; w Córdova, Luis A; Brulin, Bénédicte; Heymann, Dominique; Hulin, Philippe; Nedellec, Steven; Ishow, Eléna

Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages? Article de journal

Dans: Advanced Healthcare Materials, vol. 4, no. 17, p. 2727–2734, 2015, ISSN: 21922659.

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2022

Cadé, Marie; Muñoz-Garcia, Javier; Babuty, Antoine; Fouassier, Marc; Heymann, Marie-Francoise; Monahan, Paul E; Heymann, Dominique

FVIII at the crossroad of coagulation, bone and immune biology: Emerging evidence of biological activities beyond hemostasis Article de journal

Dans: Drug Discov Today, vol. 27, no. 1, p. 102–116, 2022, ISSN: 1878-5832.

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2021

Avnet, Sofia; Lemma, Silvia; Cortini, Margherita; Pompo, Gemma Di; Perut, Francesca; Lipreri, Maria Veronica; Roncuzzi, Laura; Columbaro, Marta; Errani, Costantino; Longhi, Alessandra; Zini, Nicoletta; Heymann, Dominique; Dominici, Massimo; Grisendi, Giulia; Golinelli, Giulia; Consolino, Lorena; Longo, Dario Livio; Nanni, Cristina; Righi, Alberto; Baldini, Nicola

The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma Article de journal

Dans: Cancers (Basel), vol. 13, no. 22, 2021, ISSN: 2072-6694.

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Muñoz-Garcia, Javier; Jubelin, Camille; Loussouarn, Aurélie; Goumard, Matisse; Griscom, Laurent; Renodon-Cornière, Axelle; Heymann, Marie-Françoise; Heymann, Dominique

In vitro three-dimensional cell cultures for bone sarcomas Article de journal

Dans: Journal of Bone Oncology, vol. 30, p. 100379, 2021, ISSN: 2212-1374.

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Danieau, Geoffroy; Morice, Sarah; Renault, Sarah; Brion, Régis; Biteau, Kevin; Amiaud, Jérôme; Cadé, Marie; Heymann, Dominique; Lézot, Frédéric; Verrecchia, Franck; Rédini, Françoise; Royer, Bénédicte Brounais-Le

ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells Article de journal

Dans: Pharmaceuticals (Basel), vol. 14, no. 5, 2021, ISSN: 1424-8247.

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Muñoz-Garcia, Javier; Mazza, Mattia; Alliot, Cyrille; Sinquin, Corinne; Colliec-Jouault, Sylvia; Heymann, Dominique; Huclier-Markai, Sandrine

Antiproliferative Properties of Scandium Exopolysaccharide Complexes on Several Cancer Cell Lines Article de journal

Dans: Mar Drugs, vol. 19, no. 3, 2021, ISSN: 1660-3397.

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Heymann, Marie-Françoise; Schiavone, Kristina; Heymann, Dominique

Bone sarcomas in the immunotherapy era Article de journal

Dans: Br J Pharmacol, vol. 178, no. 9, p. 1955–1972, 2021, ISSN: 1476-5381.

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Tabti, Redouane; Lamoureux, François; Charrier, Céline; Ory, Benjamin; Heymann, Dominique; Bentouhami, Embarek; Désaubry, Laurent

Development of prohibitin ligands against osteoporosis Article de journal

Dans: Eur J Med Chem, vol. 210, p. 112961, 2021, ISSN: 1768-3254.

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Heymann, Dominique

The Elderly and the COVID 19 Crisis: A Chronicle of Deaths Foretold, in Isolation and Total Indifference Article de journal

Dans: Front Public Health, vol. 8, p. 602982, 2021, ISSN: 2296-2565.

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Heymann, Clément J F; Bard, Jean-Marie; Heymann, Marie-Françoise; Heymann, Dominique; Bobin-Dubigeon, Christine

The intratumoral microbiome: Characterization methods and functional impact Article de journal

Dans: Cancer Lett, vol. 522, p. 63–79, 2021, ISSN: 1872-7980.

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2020

Guyon, Nina; Garnier, Delphine; Briand, Joséphine; Nadaradjane, Arulraj; Bougras-Cartron, Gwenola; Raimbourg, Judith; Campone, Mario; Heymann, Dominique; Vallette, François M; Frenel, Jean-Sébastien; Cartron, Pierre-François

Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells Article de journal

Dans: Cell Death Dis, vol. 11, no. 12, p. 1048, 2020, ISSN: 2041-4889.

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Oliver, Lisa; Lalier, Lisenn; Salaud, Céline; Heymann, Dominique; Cartron, Pierre François; Vallette, François M

Drug resistance in glioblastoma: are persisters the key to therapy? Article de journal

Dans: Cancer Drug Resistance, vol. 3, no. 3, p. 287–301, 2020.

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Briand, Joséphine; Sérandour, Aurélien A; Nadaradjane, Arulraj; Bougras-Cartron, Gwenola; Heymann, Dominique; Ory, Benjamin; Vallette, François M; Cartron, Pierre-François

N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool Article de journal

Dans: Mol Ther Nucleic Acids, vol. 22, p. 72–83, 2020, ISSN: 2162-2531.

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Briand, Joséphine; Sérandour, Aurélien A; Nadaradjane, Arulraj; Bougras-Cartron, Gwenola; Heymann, Dominique; Ory, Benjamin; Vallette, François M; Cartron, Pierre-François

N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool Article de journal

Dans: Mol Ther Nucleic Acids, vol. 22, p. 72–83, 2020, ISSN: 2162-2531.

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Heymann, Marie-Francoise; Lezot, Frederic; Heymann, Dominique

Bisphosphonates in common pediatric and adult bone sarcomas Article de journal

Dans: Bone, vol. 139, p. 115523, 2020, ISSN: 1873-2763.

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Thureau, Sébastien; Faivre, Jean Christophe; Assaker, Richard; Biver, Emmanuel; Confavreux, Cyrille B; Debiais, Françoise; Duterque-Coquillaud, Martine; Giammarile, Francesco; Heymann, Dominique; Lecouvet, Frédéric E; Morardet, Laetitia; Paycha, Frederic; Body, Jean-Jacques; Vieillard, Marie-Hélène

Adapting palliative radiation therapy for bone metastases during the Covid-19 pandemic: GEMO position paper Article de journal

Dans: J Bone Oncol, vol. 22, p. 100291, 2020, ISSN: 2212-1366.

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Briand, Joséphine; Garnier, Delphine; Nadaradjane, Arulraj; Clément-Colmou, Karen; Potiron, Vincent; Supiot, Stéphane; Bougras-Cartron, Gwenola; Frenel, Jean-Sébastien; Heymann, Dominique; Vallette, François M; Cartron, Pierre-François

Radiotherapy-induced overexpression of exosomal miRNA-378a-3p in cancer cells limits natural killer cells cytotoxicity Article de journal

Dans: Epigenomics, vol. 12, no. 5, p. 397–408, 2020, ISSN: 1750-192X.

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Heymann, Dominique; Verhille, Estelle; Veron, Vanessa; Vitre, Marie; Delmas, Florian; Henry, Cécile; Gouy, Yann; Amiand, Marie; Bard, Jean-Marie

Centre de ressources Biologiques-Tumorothèque: bioresources and associated clinical data dedicated to translational research in oncology at the institut de cancérologie de l’Ouest, France Article de journal

Dans: Open Journal of Bioresources, vol. 7, p. 5, 2020.

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Gama, Andrea; Maman, Laura; Vargas-Franco, Jorge William; Omar, Rana; Royer, Bénédicte Brounais-Le; Yagita, Hideo; Babajko, Sylvie; Berdal, Ariane; Acevedo, Ana Carolina; Heymann, Dominique; Lézot, Frédéric; Castaneda, Beatriz

Primary Retention of Molars and RANKL Signaling Alteration during Craniofacial Growth Article de journal

Dans: J Clin Med, vol. 9, no. 4, 2020, ISSN: 2077-0383.

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Gama, Andrea; Vargas-Franco, Jorge William; Mesa, Diana Carolina Sánchez; Bedoya, Elizabeth Restrepo; Amiaud, Jérome; Babajko, Sylvie; Berdal, Ariane; Acevedo, Ana Carolina; Heymann, Dominique; Lézot, Frédéric; Castaneda, Beatriz

Origins of Alterations to Null Mutant Mouse Dental Root Development Article de journal

Dans: Int J Mol Sci, vol. 21, no. 6, 2020, ISSN: 1422-0067.

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Moukengue, Brice; Brown, Hannah K; Charrier, Céline; Battaglia, Séverine; Baud'huin, Marc; Quillard, Thibaut; Pham, Therese M; Pateras, Ioannis S; Gorgoulis, Vassilis G; Helleday, Thomas; Heymann, Dominique; Berglund, Ulrika Warpman; Ory, Benjamin; Lamoureux, Francois

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model Article de journal

Dans: EBioMedicine, vol. 53, p. 102704, 2020, ISSN: 2352-3964.

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Cheray, Mathilde; Etcheverry, Amandine; Jacques, Camille; Pacaud, Romain; Bougras-Cartron, Gwenola; Aubry, Marc; Denoual, Florent; Peterlongo, Pierre; Nadaradjane, Arulraj; Briand, Joséphine; Akcha, Farida; Heymann, Dominique; Vallette, François M; Mosser, Jean; Ory, Benjamin; Cartron, Pierre-François

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme Article de journal

Dans: Mol Cancer, vol. 19, no. 1, p. 36, 2020, ISSN: 1476-4598.

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Duforestel, Manon; Briand, Joséphine; Bougras-Cartron, Gwenola; Heymann, Dominique; Frenel, Jean-Sébastien; Vallette, François M; Cartron, Pierre-François

Cell-free circulating epimarks in cancer monitoring Article de journal

Dans: Epigenomics, vol. 12, no. 2, p. 145–155, 2020, ISSN: 1750-192X.

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Grünewald, Thomas Gp; Alonso, Marta; Avnet, Sofia; Banito, Ana; Burdach, Stefan; Cidre-Aranaz, Florencia; Pompo, Gemma Di; Distel, Martin; Dorado-Garcia, Heathcliff; Garcia-Castro, Javier; González-González, Laura; Grigoriadis, Agamemnon E; Kasan, Merve; Koelsche, Christian; Krumbholz, Manuela; Lecanda, Fernando; Lemma, Silvia; Longo, Dario L; Madrigal-Esquivel, Claudia; Morales-Molina, Álvaro; Musa, Julian; Ohmura, Shunya; Ory, Benjamin; Pereira-Silva, Miguel; Perut, Francesca; Rodriguez, Rene; Seeling, Carolin; Shaaili, Nada Al; Shaabani, Shabnam; Shiavone, Kristina; Sinha, Snehadri; Tomazou, Eleni M; Trautmann, Marcel; Vela, Maria; Versleijen-Jonkers, Yvonne Mh; Visgauss, Julia; Zalacain, Marta; Schober, Sebastian J; Lissat, Andrej; English, William R; Baldini, Nicola; Heymann, Dominique

Sarcoma treatment in the era of molecular medicine Article de journal

Dans: EMBO Mol Med, vol. 12, no. 11, p. e11131, 2020, ISSN: 1757-4684.

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Mignard, Vincent; Dubois, Nolwenn; Lanoé, Didier; Joalland, Marie-Pierre; Oliver, Lisa; Pecqueur, Claire; Heymann, Dominique; Paris, François; Vallette, François M; Lalier, Lisenn

Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apoptosis Article de journal

Dans: J Lipid Res, vol. 61, no. 7, p. 1025–1037, 2020, ISSN: 1539-7262.

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2019

Taves, Sarah; Sun, Junjiang; Livingston, Eric W; Chen, Xin; Amiaud, Jerome; Brion, Regis; Hannah, William B; Bateman, Ted A; Heymann, Dominique; Monahan, Paul E

Hemophilia A and B mice, but not VWFmice, display bone defects in congenital development and remodeling after injury Article de journal

Dans: Sci Rep, vol. 9, no. 1, p. 14428, 2019, ISSN: 2045-2322.

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Alvarez, Carla; Monasterio, Gustavo; Cavalla, Franco; Córdova, Luis A; Hernández, Marcela; Heymann, Dominique; Garlet, Gustavo P; Sorsa, Timo; Pärnänen, Pirjo; Lee, Hsi-Ming; Golub, Lorne M; Vernal, Rolando; Kantarci, Alpdogan

Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms Article de journal

Dans: Front Immunol, vol. 10, p. 1664, 2019, ISSN: 1664-3224.

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Tellez-Gabriel, Marta; Heymann, Marie-Françoise; Heymann, Dominique

Circulating Tumor Cells as a Tool for Assessing Tumor Heterogeneity Article de journal

Dans: Theranostics, vol. 9, no. 16, p. 4580–4594, 2019, ISSN: 1838-7640.

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2017

Brown, Hannah K; Tellez-Gabriel, Marta; Heymann, Dominique

Cancer stem cells in osteosarcoma Article de journal

Dans: Cancer Lett, vol. 386, p. 189–195, 2017, ISSN: 1872-7980.

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Liens