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@article{TeletcheaTNF2025,

title = {Molecular determinants of TNFR1:TNFα binding and dynamics in a physiological membrane environment},

author = {Elena Álvarez-Sánchez and Simon Huet and Stéphane Téletchéa},

editor = {Elsevier},

doi = {10.1016/j.crstbi.2025.100177},

year  = {2026},

date = {2026-06-01},

urldate = {2025-12-18},

journal = {Current Research in Structural Biology},

volume = {26},

pages = {100177},

abstract = {Tumor Necrosis Factor alpha (TNFα) is a pro-inflammatory cytokine critical for regulating cell survival and death. Under pathological conditions, excessive TNFα activity can lead to chronic inflammation, contributing to diseases such as inflammatory bowel disease and other autoimmune disorders. While structural studies have elucidated the atomistic details of TNFα binding to its receptor, TNF Receptor 1 (TNFR1), the influence of the membrane environment on this interaction remains poorly characterized experimentally. In this study, we employed advanced all-atom Gaussian accelerated molecular dynamics simulations to investigate how lipid-mediated interactions modulate the TNFα–TNFR1 complex. We identified key residues on both the cytokine and its receptor that govern trimer assembly, receptor binding, and potential pathological alterations. Our analysis confirmed previously identified functional sites and revealed new residues likely to contribute to the structural stability and dynamics of the complex. These findings provide a more comprehensive understanding of the molecular determinants of TNF signaling and offer a foundation for future experimental investigations into the receptor-ligand interface and membrane-mediated regulation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gamage2026b,

title = {Characterising key bacterial taxa of the benthic diatom Amphora sp. biofilms in a porous substrate photobioreactor},

author = {Nadeeshani Dehel Gamage and Paul Déléris and Leïla Tirichine and Gaëtane Wielgosz-Collin and Thierry Lebeau and Aurélie Mossion and Vona Méléder},

doi = {10.1016/j.biteb.2026.102686},

issn = {2589-014X},

year  = {2026},

date = {2026-06-00},

urldate = {2026-06-00},

journal = {Bioresource Technology Reports},

volume = {34},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Trojani2026,

title = {\textit{Atg5}                    /Autophagy inactivation in mouse bone microenvironment promotes tumor development},

author = {Marie-Charlotte Trojani and Marie Nollet and Olivier Camuzard and Sabine Santucci-Darmanin and Véronique Breuil and Fanny Burel-Vandenbos and Laurie Fradet and Morgane Le Gall and Virginie Salnot and Dominique Heymann and Georges F. Carle and Valérie Pierrefite-Carle},

url = {https://hal.science/inserm-05495812v1},

doi = {10.1080/15548627.2026.2624756},

issn = {1554-8635},

year  = {2026},

date = {2026-05-04},

urldate = {2026-05-04},

journal = {Autophagy},

volume = {22},

number = {5},

pages = {1063--1080},

publisher = {Informa UK Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid41813666,

title = {Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice},

author = {Antoine Babuty and Javier Muñoz-Garcia and Olivier D Christophe and Laurie Fradet and Manon Taupin and Denis Cochonneau and Emilie Ollivier and Frank Driessler and Claudia Lange and Oleksandr Boychenko and Marie-Françoise Heymann and Dominique Heymann},

url = {https://hal.science/hal-05319155v1},

doi = {10.1038/s41413-025-00485-2},

issn = {2095-4700},

year  = {2026},

date = {2026-03-01},

urldate = {2026-03-01},

journal = {Bone Res},

volume = {14},

number = {1},

abstract = {In addition to its role in hemostasis, Factor VIII (FVIII) has recently been shown to potentially impact angiogenesis, inflammation, osteopenia, and sarcopenia. This was explored here by studying the musculoskeletal development of FVIII knockout (FVIII) male mice. These animals developed an osteoporotic phenotype with significant bone microarchitectural alteration, reduced vascularization, and a lower osteoblastic population. Proteomic analyses revealed differentiating bone metabolism-related proteins between FVIII and wildtype mice. Weekly infusions of recombinant FVIII protein reversed this phenotype. Surprisingly, younger FVIII mice had heavier muscles with larger fibers, shifted from type IIx to type IIb, not reversed by FVIII treatment. Significant proteomic and metabolomic differences between wildtype and FVIII muscles were observed, some of which were reduced by FVIII treatment. This study provides the first comprehensive full-phenotypic characterization of bones and muscles in FVIII mice and demonstrates the benefits of FVIII supplementation to normalize their musculoskeletal phenotype.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rousseau2025,

title = {Prospective pilot study with [89Zr]Zr-girentuximab PET/CT: CA-IX imaging in metastatic triple negative breast cancer (OPALESCENCE)},

author = {Caroline Rousseau and M. F. Heyman and L. Ferrer and A. Rauscher and A. Morel and D. Rusu and JS Frenel and M. Taupin and L. Vilcot and N. Allam and M. Robert and M. Campone and L. Campion and F. Kraeber-Bodéré},

url = {https://hal.science/hal-05478233v1},

doi = {10.1007/s00259-025-07619-y},

issn = {1619-7089},

year  = {2026},

date = {2026-03-00},

urldate = {2026-03-00},

journal = {Eur J Nucl Med Mol Imaging},

volume = {53},

number = {4},

pages = {2403--2413},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}