Accueil

@article{nokey,

title = {Tetraploidy in cancer: Diagnostic and therapeutic perspectives},

author = {Lessa A and Levergeois R and Muños-Garcia J and Mountford J and Vargas-Franco JW and Cochonneau D and Renodon-Cornière A and Heymann MF and Giurgea I and Heymann D and Lézot F.},

url = {https://hal.science/hal-05700594v1},

doi = {10.1016/j.bcp.2026.118157},

year  = {2026},

date = {2026-07-10},

urldate = {2026-07-10},

journal = {Biochem Pharmacol},

volume = {251},

pages = {118157},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Three-dimensional cell cultures: Applications to cancer biology},

author = {Jubelin C and Golias M and Cochonneau D and Muñoz-Garcia J and Heymann D.},

doi = {10.1016/j.bulcan.2025.09.004},

year  = {2026},

date = {2026-07-10},

urldate = {2026-07-10},

journal = {Bull Cancer},

volume = {113},

issue = {1},

pages = {26-47},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{TeletcheaTNF2025,

title = {Molecular determinants of TNFR1:TNFα binding and dynamics in a physiological membrane environment},

author = {Elena Álvarez-Sánchez and Simon Huet and Stéphane Téletchéa},

editor = {Elsevier},

doi = {10.1016/j.crstbi.2025.100177},

year  = {2026},

date = {2026-06-01},

urldate = {2025-12-18},

journal = {Current Research in Structural Biology},

volume = {26},

pages = {100177},

abstract = {Tumor Necrosis Factor alpha (TNFα) is a pro-inflammatory cytokine critical for regulating cell survival and death. Under pathological conditions, excessive TNFα activity can lead to chronic inflammation, contributing to diseases such as inflammatory bowel disease and other autoimmune disorders. While structural studies have elucidated the atomistic details of TNFα binding to its receptor, TNF Receptor 1 (TNFR1), the influence of the membrane environment on this interaction remains poorly characterized experimentally. In this study, we employed advanced all-atom Gaussian accelerated molecular dynamics simulations to investigate how lipid-mediated interactions modulate the TNFα–TNFR1 complex. We identified key residues on both the cytokine and its receptor that govern trimer assembly, receptor binding, and potential pathological alterations. Our analysis confirmed previously identified functional sites and revealed new residues likely to contribute to the structural stability and dynamics of the complex. These findings provide a more comprehensive understanding of the molecular determinants of TNF signaling and offer a foundation for future experimental investigations into the receptor-ligand interface and membrane-mediated regulation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gamage2026b,

title = {Characterising key bacterial taxa of the benthic diatom Amphora sp. biofilms in a porous substrate photobioreactor},

author = {Nadeeshani Dehel Gamage and Paul Déléris and Leïla Tirichine and Gaëtane Wielgosz-Collin and Thierry Lebeau and Aurélie Mossion and Vona Méléder},

url = {https://nantes-universite.hal.science/hal-05695439v1},

doi = {10.1016/j.biteb.2026.102686},

issn = {2589-014X},

year  = {2026},

date = {2026-06-00},

urldate = {2026-06-00},

journal = {Bioresource Technology Reports},

volume = {34},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Trojani2026,

title = {\textit{Atg5}                    /Autophagy inactivation in mouse bone microenvironment promotes tumor development},

author = {Marie-Charlotte Trojani and Marie Nollet and Olivier Camuzard and Sabine Santucci-Darmanin and Véronique Breuil and Fanny Burel-Vandenbos and Laurie Fradet and Morgane Le Gall and Virginie Salnot and Dominique Heymann and Georges F. Carle and Valérie Pierrefite-Carle},

url = {https://hal.science/inserm-05495812v1},

doi = {10.1080/15548627.2026.2624756},

issn = {1554-8635},

year  = {2026},

date = {2026-05-04},

urldate = {2026-05-04},

journal = {Autophagy},

volume = {22},

number = {5},

pages = {1063--1080},

publisher = {Informa UK Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}