The role of IMMune Osteoclasts in CANcer – Implications for therapy
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- Début du projet : 01/09/2023
- Fin du projet : 31/12/2026
Bone tumors and bone metastasis affect patients from children to elderly. Despite advances in diagnosis and treatment, they are incurable and thus, new therapies are needed. In the bone microenvironment, cancer cells disrupt the physiological balance between bone-forming osteoblasts, bone-resorbing osteoclasts and immune cells, leading to excessive bone destruction and promoting cancer development. Standard treatments include chemotherapy, radiation, anti-resorptive therapies and immunotherapies. However, the bone environment is largely immunosuppressive, which renders patients with bone tumors less responsive to such treatments. Importantly, recent findings including from our consortium identified specific bone cells that can link bone destruction and immune suppression and therefore may represent key players in the development of bone cancer and metastasis. The goal of the IMMOSCAN consortium is to uncover the role and mechanisms of action of these bone cells in bone cancer and metastasis. The IMMOSCAN consortium combines complementary and interdisciplinary strengths of five partners that bring together pre-clinical models and patient samples as well as state-of-the art technologies allowing to characterize bone cell specificity, function and location in the bone environment, and how they interact with each other to induce or maintain immunosuppression and cancer development. During the course of the project, we aim to identify and characterize these cells in the bone-cancer microenvironment and explore mechanisms to target them as a novel therapeutic strategy to improve the efficacy of immunotherapy and control tumor progression in bone. The findings of the project are expected to increase our understanding of the complex bone-cancer microenvironment and identify novel targetable pathways for innovative immune therapy in bone cancers.
Consortium : Ludwig-Maximilians-University Munich (Hanna Taipaleenmäki) / University of L’Aquila (Anna Teti) / Université Nice Côte d’Azur, CRNS (Claudine Blin Wakach) / University of Southern Denmark (Thomas Andersen) / Nantes Université, CNRS (Dominique Heymann)
Chercheurs impliqués : J. Muñoz-Garcia, D. Klusa
Website :Main page | IMMOSCAN
