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@article{Veronesi2024,

title = {(±)‐Catechins inhibit prehaustorium formation in the parasitic weed <scp>\textit{Phelipanche ramosa}</scp> and reduce tomato infestation},

author = {Christophe Veronesi and Estelle Billard and Philippe Delavault and Philippe Simier},

doi = {10.1002/ps.8472},

issn = {1526-4998},

year  = {2025},

date = {2025-02-01},

urldate = {2025-02-01},

journal = {Pest Management Science},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND</jats:title><jats:p><jats:italic>Phelipanche ramosa</jats:italic> L. (Pomel) is a noxious parasitic weed in field and vegetable crops in Mediterranean countries. Control of this pest is complex and far from being achieved, and new environmentally‐friendly strategies are being sought. The present study evaluates the possibility of using (±)‐catechins as a natural herbicide against broomrapes.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>The results show that (±)‐catechins have no effect on GR24‐induced germination over a wide concentration range (10<jats:sup>−4</jats:sup> to 10<jats:sup>−10</jats:sup> <jats:sc>m</jats:sc>), nor on radicle elongation after germination, but strongly inhibit, at 10<jats:sup>−4</jats:sup> and 10<jats:sup>−5</jats:sup> <jats:sc>m</jats:sc>, prehaustorium formation in response to the haustorium‐inducing factor, <jats:italic>cis/trans</jats:italic>‐zeatin. Accordingly, pot experiments involving the supplies of 10<jats:sup>−5</jats:sup> <jats:sc>m</jats:sc> of (±)‐catechins to tomato plants infested or not with <jats:italic>P</jats:italic>. <jats:italic>ramosa</jats:italic> demonstrate that (±)‐catechins do not influence growth of non‐parasitized tomato plants and prevent heavy infestation by strongly reducing parasite attachments and inducing parasite necrosis once they are attached.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION</jats:title><jats:p>This study points the potential use of (±)‐catechins for parasitic weed control. It raises also the question of the mechanisms involved in the inhibition of prehaustorium formation and the necrosis of parasite attachments in response to (±)‐catechins application. © 2024 The Author(s). <jats:italic>Pest Management Science</jats:italic> published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.</jats:p></jats:sec>},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Young2024,

title = {CIRCUS: CIRCUlating tumour cells in soft tissue Sarcoma - a short report},

author = {Robin J. Young and Joanna E. Chowdry and Denis Cochonneau and Dominique Heymann},

doi = {10.20517/cdr.2024.149},

issn = {2578-532X},

year  = {2024},

date = {2024-12-13},

urldate = {2024-12-13},

journal = {Cancer Drug Resist},

publisher = {OAE Publishing Inc.},

abstract = {Aims:  Circulating tumour cells (CTCs) can be detected in peripheral blood using their physical properties (increased size and less deformable than normal circulating blood cells) or using cell surface markers. The study of these CTCs should provide important insights into tumour biology, including mechanisms of drug resistance. We performed a pilot study (IRAS ID: 235459) to evaluate if CTCs could be isolated from peripheral blood samples collected from soft tissue sarcoma (STS) patients.

Methods:  We used a combined approach that first enriched samples for CTCs using a microfluidic cassette via ParosrtixTMPR1, and then sorted cells stained for vimentin and cytokeratin using the DEPArrayTM. The total circulating cell-free DNA (cfDNA) level was also analysed. Data were correlated with clinical parameters.

Results:  13 patients were recruited to this study: 7 patients with localised disease and 6 patients with metastatic disease. CTCs exhibited a high heterogeneity based on their expression of mesenchymal and epithelial biomarkers. There was no significant difference in the number of CTCs between patients with localised versus metastatic disease. We observed no correlation between CTC numbers and cfDNA; however, the number of CTCs did correlate with primary tumour size.

Conclusion:  The present study demonstrates the presence of CTCs in STS patients with localised and advanced disease. Further and larger studies are needed to characterise STS CTCs and to evaluate their prognostic significance.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Oliver2024,

title = {Transcriptional landscape of the interaction of human Mesenchymal Stem Cells with Glioblastoma in bioprinted co-cultures},

author = {Lisa Oliver and Yuna Landais and Catherine Gratas and Pierre-François Cartron and François Paris and Dominique Heymann and François M. Vallette and Aurelien Serandour},

doi = {10.1186/s13287-024-04022-6},

issn = {1757-6512},

year  = {2024},

date = {2024-12-00},

urldate = {2024-12-00},

journal = {Stem Cell Res Ther},

volume = {15},

number = {1},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}