@article{BaudinMarie2026b,

title = {Targeting sialic acid catabolism with polyvalent sialidase inhibitors to mitigate bacterial inflammation in the gut},

author = {Mélyne Baudin Marie and Zoé Oblette and Mathieu Scalabrini and Denis Loquet and Devon W. Kavanaugh and David Deniaud and Thomas Bessonnet and Nizar Amzil and Aziz Elgarrab and Cyrille Grandjean and Clément Gonnot and Fabien Boeda and Laurent Fontaine and Véronique Montembault and Franck Daligault and Nicolas Barnich and Adeline Sivignon and Sébastien G. Gouin},

url = {https://hal.science/hal-05628951v1},

doi = {10.1016/j.bioorg.2025.109283},

issn = {0045-2068},

year  = {2026},

date = {2026-01-00},

urldate = {2026-01-00},

journal = {Bioorganic Chemistry},

volume = {168},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Laneque2025,

title = {Mutagenesis to Orient Conjugation and Preserve Self‐adjuvant Properties of Flagellin in Conjugates},

author = {Laura Laneque and Annie Lambert and Delphine Cayet and Caroline Gilleron and Emmanuelle Courtois and Chloé Cloteau and Cédric Broussard and Bastien Annic and Thomas Bessonnet and Emilie Camberlein and Jean‐Claude Sirard and Cyrille Grandjean},

url = {https://hal.science/hal-04940464v1},

doi = {10.1002/cbic.202401002},

issn = {1439-7633},

year  = {2025},

date = {2025-04-14},

urldate = {2025-04-14},

journal = {ChemBioChem},

volume = {26},

number = {8},

publisher = {Wiley},

abstract = {<jats:title>Abstract</jats:title><jats:p>Bacterial flagellins are unique for their capacity to activate both the innate and the adaptive immune response through a Toll‐like receptor 5 (TLR5) signaling cascade. Used as a carrier protein in conjugate vaccines, it is crucial to preserve their self‐adjuvant properties during the conjugation step. Considering the absence of cysteine in the <jats:italic>Salmonella enterica</jats:italic> flagellin FliC sequence, we have investigated the impact of five mutations (A2 C, K180 C, T240 C, D251 C and S306 C) alone or in combination on TLR5 activation. The FliC mutated at the four positions K180 C, T240 C, D251 C and S306 C displayed much the same activity as native flagellin whether the cysteine residues were free or conjugated. These results pave the way for the preparation of self‐adjuvanting conjugate vaccines based on cysteine‐mutated FliC as a carrier protein.</jats:p>},

keywords = {},

pubstate = {published},

tppubtype = {article}

}