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@article{nokey,

title = {Genomic sequences and annotations of two Pseudomonas species isolated from marine and terrestrial habitats},

author = {Eric Manirakiza and Timothée Chaumier and Leïla Tirichine},

editor = {ASM Journals},

doi = { https://doi.org/10.1128/mra.00373-24},

year  = {2024},

date = {2024-08-27},

journal = {Microbiol Resour Announc .},

volume = {-},

number = {-},

issue = {-},

pages = {e0037324},

abstract = {Here, we present the complete genome sequences and annotations of two species of the Pseudomonas genus isolated from marine and terrestrial environments. Both genomes and their annotations are available on BacBrowse (https://BacBrowse.univ-nantes.fr). This study will contribute to a better understanding of the diversity present within the Pseudomonas genus.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {H3K27me3 and EZH Are Involved in the Control of the Heat-Stress-Elicited Morphological Changes in Diatoms},

author = {Mhammad Zarif and Ellyn Rousselot and Bruno Jesus and Leïla Tirichine and Céline Duc},

editor = {MDPI},

url = {https://www.mdpi.com/1422-0067/25/15/8373},

doi = {doi.org/10.3390/ijms25158373},

year  = {2024},

date = {2024-07-31},

journal = {Int. J. Mol. Sci.},

volume = {25},

issue = {15},

pages = {8373},

abstract = {Marine water temperatures are increasing due to anthropogenic climate change, constituting a major threat to marine ecosystems. Diatoms are major marine primary producers, and as such, they are subjected to marine heat waves and rising ocean temperatures. Additionally, under low tide, diatoms are regularly exposed to high temperatures. However, physiological and epigenetic responses to long-term exposure to heat stress remain largely unknown in the diatom Phaeodactylum tricornutum. In this study, we investigated changes in cell morphology, photosynthesis, and H3K27me3 abundance (an epigenetic mark consisting of the tri-methylation of lysine 27 on histone H3) after moderate and elevated heat stresses. Mutants impaired in PtEZH—the enzyme depositing H3K27me3—presented reduced growth and moderate changes in their PSII quantum capacities. We observed shape changes for the three morphotypes of P. tricornutum (fusiform, oval, and triradiate) in response to heat stress. These changes were found to be under the control of PtEZH. Additionally, both moderate and elevated heat stresses modulated the expression of genes encoding proteins involved in photosynthesis. Finally, heat stress elicited a reduction of genome-wide H3K27me3 levels in the various morphotypes. Hence, we provided direct evidence of epigenetic control of the H3K27me3 mark in the responses of Phaeodactylum tricornutum to heat stress.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38938184,

title = {Multivalent inhibition of the  fumigatus KDNase},

author = {Mathieu Scalabrini and Denis Loquet and Camille Rochard and Mélyne Baudin Marie and Coralie Assailly and Yoan Brissonnet and Franck Daligault and Amélie Saumonneau and Annie Lambert and Cyrille Grandjean and David Deniaud and Paul Lottin and Sagrario Pascual and Laurent Fontaine and Viviane Balloy and Sébastien G Gouin},

doi = {10.1039/d4ob00601a},

issn = {1477-0539},

year  = {2024},

date = {2024-07-01},

urldate = {2024-07-01},

journal = {Org Biomol Chem},

volume = {22},

number = {28},

pages = {5783--5789},

abstract = { is a saprophytic fungus and opportunistic pathogen often causing fatal infections in immunocompromised patients. Recently KDNAse, an exoglycosidase hydrolyzing 3-deoxy-D-galacto-D--nonulosonic acid (KDN), a rare sugar from the sialic acid family, was identified and characterized. The principal function of KDNAse is still unclear, but a study suggests a critical role in fungal cell wall morphology and virulence. Potent KDNAse inhibitors are required to better probe the enzyme's biological role and as potential antivirulence factors. In this work, we developed a set of KDNAse inhibitors based on enzymatically stable thio-KDN motifs. C2, C9-linked heterodi-KDN were designed to fit into unusually close KDN sugar binding pockets in the protein. A polymeric compound with an average of 54 KDN motifs was also designed by click chemistry. Inhibitory assays performed on recombinant KDNAse showed a moderate and strong enzymatic inhibition for the two classes of compounds, respectively. The poly-KDN showed more than a nine hundred fold improved inhibitory activity (IC = 1.52 ± 0.37 μM, 17-fold in a KDN molar basis) compared to a monovalent KDN reference, and is to our knowledge, the best synthetic inhibitor described for a KDNase. Multivalency appears to be a relevant strategy for the design of potent KDNase inhibitors. Importantly, poly-KDN was shown to strongly decrease filamentation when co-cultured with  at micromolar concentrations, opening interesting perspectives in the development of antivirulence factors.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid38529534,

title = {Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis},

author = {Dávid Roman and Philippe Meisinger and Richard Guillonneau and Chia-Chi Peng and Lukas K Peltner and Paul M Jordan and Veit Haensch and Sebastian Götze and Oliver Werz and Christian Hertweck and Yin Chen and Christine Beemelmanns},

url = { hal-04587238v1 },

doi = {10.1002/anie.202401195},

issn = {1521-3773},

year  = {2024},

date = {2024-06-01},

urldate = {2024-06-01},

journal = {Angew Chem Int Ed Engl},

volume = {63},

number = {23},

pages = {e202401195},

abstract = {The cosmopolitan marine Roseobacter clade is of global biogeochemical importance. Members of this clade produce sulfur-containing amino lipids (SALs) involved in biofilm formation and marine surface colonization processes. Despite their physiological relevance and abundance, SALs have only been explored through genomic mining approaches and lipidomic studies based on mass spectrometry, which left the relative and absolute structures of SALs unresolved, hindering progress in biochemical and functional investigations. Herein, we report the structural revision of a new group of SALs, which we named cysteinolides, using a combination of analytical techniques, isolation and degradation experiments and total synthetic efforts. Contrary to the previously proposed homotaurine-based structures, cysteinolides are composed of an N,O-acylated cysteinolic acid-containing head group carrying various different (α-hydroxy)carboxylic acids. We also performed the first validated targeted-network based analysis, which allowed us to map the distribution and structural diversity of cysteinolides across bacterial lineages. Beyond offering structural insight, our research provides SAL standards and validated analytical data. This information holds significance for forthcoming investigations into bacterial sulfonolipid metabolism and biogeochemical nutrient cycling within marine environments.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{cordova_why_2024,

title = {Why are osteoporosis patients treated with antiresorptive therapies considered like oncology patients regarding their oral health care?},

author = {Luis A. Cordova and David González-Quintanilla and Dominique Heymann},

url = {https://doi.org/10.1007/s00198-024-07173-7},

doi = {10.1007/s00198-024-07173-7},

issn = {1433-2965},

year  = {2024},

date = {2024-06-01},

urldate = {2024-06-01},

journal = {Osteoporosis International},

keywords = {},

pubstate = {published},

tppubtype = {article}

}